Top: a physicochemical view of the synthesis of a human, each person having a Gibbs free energy of formation (see: human free energy of formation), according to the views of, e.g. Norman Dolloff (1975), Martin Goldstein (1993), Daniel Schroeder (2000), and Libb Thims (2010). Bottom: a depiction of the new 21st century human molecular formula based view of humans as reactive "molecules" with a measured 22- or 26-element, depending, molecular formula, as found in the following three textbooks: Ecological Stoichiometry (2002), by American limnologists Robert Sterner and James Elser, Human Chemistry (2007), by American electrochemical engineer Libb Thims, and Advanced Engineering Thermodynamics (2011), by Indian-born American mechanical engineer Kalyan Annamalai and American mechanical engineer Carlos Silva, the latter citing Thims’ human molecular formula definition, all tracing their origin to French philosopher Jean Sales 1789 "human molecular hypothesis" in his The Philosophy of Nature: Treatise on Human Moral Nature. [25] |
Human = f{C, H, O,}
Human = f{O, C, H, N, S, P, Cl, Na, K, Ca, Mg, Fe, Fl, S}
26-elements | Chemical formula | C:N:P ratio |
Henry Osborn (1857-1935) | George Carey (1845-1924) | Alfred Redfield (1890-1983) |
“The human body contains carbon, 13.5 percent; hydrogen, 9.1 percent; oxygen, 72 percent; nitrogen, 2.5 percent; phosphorus, 1.15 percent; sodium, 0.1 percent; calcium, 1.3 percent; magnesium, 0.001 percent; iron, 0.01 percent and traces of silicon and fluorine.”
“The earliest fitness we discover in the bacteria or monad is the fitness of grouping and organizing different kinds of energy—the energy of molecules, of atoms, of electrons as displayed in the twenty-six or more chemical elements which enter into life.”
“Man's body is a chemical formula in operation.”
Human = f{C, H, O, N}
C:N:P = 106:16:1
Human = F{O, C, H, N, Ca, P, K, S, Na, Cl, Mg, Fe, Cu, Mo, Zn, I}In the mid 1970s, it was being reported, in publications such as San Jose Mercury News (“Man’s Worth Rises, Chemically Speaking”, 1972), Chemical and Engineering News, and high school science textbooks, supposedly, originating as a joke by someone, that it “used to be common knowledge that, from head to toe, the chemical value of the human body was 98 cents”; the joke supposedly became funnier by reporting inflation values each year: $3.50 (1972), $5.60 (1977), and $6M (1976) by Harold Morowitz. (Ѻ)
A 2001 periodic table listing of elements found to have function or possibly have function in animate organisms. [13] |
See main: Sterner-Elser human molecular formulaOn 18 Apr 2000, or circa thereabouts, inspired by the earlier 1934-1958 C:N:P ratio plankton composition work of American oceanographer Alfred Redfield, the first calculation of the empirical molecular formula for an average human was done by American limnologists Robert Sterner and James Elser who determined the following 22-element human empirical molecular formula for an average human: [2]
(Sterner-Elser)
[empirical]= H375,000,000O132,000,000C85,700,000N6,430,000Ca1,500,000P1,020,000S206,000Na183,000K177,000 Cl127,000Mg40,000Si38,600Fe2,680Zn2,110Cu76I14Mn13F13Cr7Se4Mo3Co1
Robert Sterner | |
Ecological Stoichiometry (2002) | James Elser |
“This formula combines all compounds in a human into single abstract ‘molecule’. The stoichiometric approach considers whole organisms as if they were single abstract molecules. Organisms can be thought of as complex evolved chemical substances that interact with each other and the abiotic world in a way that resembles a complex, composite, chemical reaction. This formula for the ‘human molecule’ [allows one] to think about how every human represents the coming together of atoms in proportions that are, if not constant, at least bounded and obeying some rules.”
“We conclude that there exists a principle of the human body which comes from the great process in which so many millions of atoms of the earth become many millions of human molecules.”
“I have attached the spreadsheet used to construct that formula for a human molecule in our book. My copy of the spreadsheet is dated April 18, 2000. I cannot say exactly when we made the calculations. That date might have to do with some modification of the figure or some other edit. At any rate, it gives an indication.”
"I want to ask you a question to clarify your point of view. My question is that on page two you state: 'the stoichiometric approach considers whole organisms as if they were single abstract molecules' (this is good); but then you state: 'while this is, of course, not strictly true ...' Could you please clarify you mindset, on the 'not strictly true' part, so that I can present you view correctly in my [upcoming] book [The Human Molecule]."
"Dr. Elser and I were trying to get across that by considering all elements to be part of one single, abstract molecule, one loses all the information inherent in the actual distribution of elements within actual biomolecules."Some, such as American civil-ecological engineer Jeff Tuhtan (2012), have taken the sentence addition fragment "while this is not strictly true" to mean that Sterner and Elser "do not view a human as an abstract molecule", which of course contradicts their explicit statement of "the stoichiometric approach considers whole organisms as if they were single abstract molecules." [19] Whatever the case, Sterner and Elser seem to be the first to ever calculate the molecular formula of a human.
What exactly is a human? | → | |
Top: a circa 2002 off-the-cuff quickly-made scratch-paper attempt of the calculation of the human molecular formula for a typical human, i.e. a crude-version molecular formula for a human, by American electrochemical engineer Libb Thims, using a percentage ratio method; arrived at during the writing of a three-volume unpublished manuscript, entitled Human Thermodynamics (see: publications, unpublished section), following about seven years worth of thought on how to model human reproduction as a chemical reaction (no analogy), of the form A + B → C (where A is a man, B a woman, and C a newly conceived child), in terms of the spontaneity criterion. [10] Right: one of Libb Thims’ early spread sheets (Ѻ), saved as “human formula”, for the calculation of the average human molecular formula, shown online in 2005. |
Thims human molecular formulaThe second-known calculation of both the empirical human molecular formula (formula showing the smallest ratio of atoms) and the human molecular formula (formula showing all of the atoms present in the molecule) was done, independently, by American electrochemical engineer Libb Thims in 2002, specifically in a manuscript chapter to a three-volume textbook Human Thermodynamics, in a chapter entitled "Where Does One Go after Death?" on the question of what happens when you die, in the context of the conservation of energy and thermodynamics. To give a bit of preliminary, from 1995 to 2001, Thims had been working on the famous elective affinities problem, in the form of how to predict the reaction feasibility of birth or synthesis of a human using the Gibbs function reaction spontaneity criterion applied to the following human reproduction reaction model:
A + B → C
(Thims)
[empirical]= H2.5E9O9.7E8C4.9E8N4.7E7P9.0E6Ca8.9E6K2.0E6Na1.9E6S1.6E6Cl1.3E6Mg3.0E5Fe5.5E4
F5.4E4Zn1.2E4Si9.1E3Cu1.2E3B7.1E2Cr98Mn93Ni87Se65Sn64I60Mo19Co17V
(Thims)
[molecular]= CE27HE27OE27NE26PE25SE24CaE25KE24ClE24NaE24MgE24FeE23FE23
ZnE22SiE22CuE21BE21IE20SnE20MnE20SeE20CrE20NiE20MoE19CoE19VE18
Libb Thims | |||
Human Chemistry (2007) | The Human Molecule (2008) |
"By describing the existence of a human in this form we are by no means making attempts to degrade our existence, we are only trying to help elucidate our understanding of this existence.”
(New Scientist)
[empirical]= H15,750N31006,500C2,250Ca63P48K15S15Na10Cl6Mg3Fe1
_____The 03 Dec 2005 New Scientist issue containing the article "That's Life", opening section shown above, which gives a 12-element empirical molecular formula for a human. [7]
"What chemical formula would accurately describe an adult human being, in terms of the relative distribution of elements (including pollutants)? And what might be the formula for the first alien life form we encounter? One's "chemical formula" depends on a number of factors, most notably whether we're talking about a he or a she. Male bodies contain more water than female bodies, which have extra lipids. By weight, oxygen amounts to about two-thirds of the body, followed by carbon at 20 per cent, hydrogen at 10 per cent and nitrogen at 3 per cent. Elements originating from pollutants would only be present in trace amounts. If a human body were broken into single atoms, we would arrive at an empirical formula H15750 N310 O6500 C2250 Ca63 P48 K15 S15 Na10 Cl6 Mg3 Fe1. The relative numbers of atoms in this differ from the composition by weight because atoms have ..."
(2007) | (2010) | (2012) | |
In ecology, the three books to the left employ the Sterner-Elser human molecular formula employing books, the book to the right, an ecological thermodynamics PhD dissertation by Jeff Tuhtan, to the right employs the Thims human molecular formula, in particular the concept of the fish molecule. |
“The practitioners of biological stoichiometry do not question the importance of physiology and biochemistry, rather they attempt to use the metaphor of living systems as molecules in an attempt to construct a minimal, but more complete, ecological theory than one based on a single currency (energy, or carbon, or nitrogen).”
William Karasov and Carlos del Rio Physiological Ecology (2007) | _________ | Robert Sterner and James Elser Encyclopedia of Ecology (2008) |
“The human species is but one of many. Viewed from a sort of universal microscope, we appear as but a vast collection of molecules in motion. In our current state we are firmly attached to an Earthly substrate, feeding off the energy gradient of the Sun. The fate of our chemical species is undeniably tied to the affinities and energies of interaction required to maintain our evolving earth ecosystem. We live in a closed system. In order to understand the nature of things, we must learn more about both our reactions and our products.”
The new 2011 thermodynamics textbook definition of a human, based on American electrochemical engineer Libb Thims' 2002 calculation of the 26-element human molecular formula, in Indian-born American mechanical engineers Kalyan Annamalai, Ishwar Puri, and Milind Jog’s Advanced Engineering Thermodynamics. [2] |
“Humans may be called a 26-element energy/heat driven dynamic atomic structure.”
Commenting about this, in end note commentary: [33]
2013 | 2013 |
Left a God vs Thims (compare: God vs Gibbs) labeled image from the 2013 Triple≡Bond Chemistry (triplenlace.com) article “Chemical Formula of a Human”, showing the religious implications of human molecular formula work. Right: the 2013 Debates of the Hmolpedians by David Bossens, on the philosophical implications of human molecular formula theory. |
“This is of course not a true chemical formula, as the ratios of elements in us [see: hmolscience periodic table] compose not a single unique molecule, like a crystal of salt, but a body consisting of numberous different kinds of them.”
Harkup then comments, hastily, the time-honored regurgitation statement: “Of the 59 elements detected only 23 are essential for life (although the role of some such as Si is still debated)”; as to passingly imply that 36 of the above elements, e.g. arsenic (As) "a poison", rubidium (Rb) a "muscle toxin", tungsten (W) a toxin found near waste sites, which causes "respiratory" problems in animals, lead (Pb) a "poison" common to children, aluminum (Al) a "toxin", etc., were somehow organism-functional working elements in humans; which is not the case. Maybe she should have spent more time then a "sunny afternoon" working on her formula calculation?
The 2015 entries for “molecular” [left] (Ѻ) and “empirical” [right] (Ѻ) molecular formulas for an average human, in Harvard’s Medical School’ BioNumbers, per citation of American electrochemical engineer Libb Thims 26-element “human molecular formula” (see: Thims human molecular formula (2002); compare: Sterner-Elser human molecular formula (2000), a 22-element formula). |
Incorrect | 32-elements | |
Correct | 26-elements | |
“You state "Hanson's periodic table is incorrect, in that there are six elements listed, namely: Sr, Ba, W, Cd, As, Br, not a functional part of the molecular formula of a existive human." If you watch our video, you'll hear the dialogue states "just over 30 of them are known to be essential to some form of life on earth" and our graphic/list is not limited to human biology as you've incorrectly stated. Here's some references for you:You seem to have good intentions with your site, but we'd like anyone who finds it to not be misinformed about our work.”
- Srdoi:10.1023/B:HYDR.0000027333.02017.50
- Ba doi:10.1016/j.jsb.2011.08.006
- Wdoi:10.1021/cr950063d
- Cddoi:10.1038/435042a
- As doi:10.1021/es035440f
- Brdoi:10.1039/A900201D
A 2007 Yahoo Answers “What is the Chemical Formula for a Human”, with best answer given by David C (Ѻ), via citation paste of the 2005 online version (Ѻ) of the Thims human molecular formula (2002). |