Manfred EigenIn existographies, Manfred Eigen (1927-) is a German bio-physical chemist (chnops-physical chemist) noted for his 1971 "Molecular Self-Organization and Evolution" article wherein he proposed an origin of life theory according to which living systems might have emerged from some non-living autocatalytic chemical reactions. [1]

Autocatalytic | Reproduction
See also: Stuart Kauffman (1993 auto-catalytic closure theory)
In 1971, Eigen, in his “Self-Organization of Matter and the Evolution of Biological Macromolecules”, postulated the following diagram of his idea of autocatalytic reproduction: [4]

Eigen autocatalytic reproduction

Here we see what seems, visually speaking, to be a chemical perpetual motion device.

Goethe | Human chemistry
Eigen’s 1981 book Laws of the Game, co-written with Ruthild Winkler, contains a rare English-translation of German polymath Johann Goethe’s famous 1796 Third Lecture On Anatomy—the launching point for the science of human chemistry—header section: ‘On the Laws of Organization as Such, to the Extent That We Can Observe Them in the Structure of Types’, wherein Goethe first introduces his newly conceived human elective affinity theory (see: Goethe timeline):

“To facilitate our comprehension of the concept of organic existence, let us first take a look at mineral structures. Minerals, whose varied components are so solid and unchanging, do not seem to hold to any limits or order when then combine, although laws do determine these conditions. Different components can be easily separated and recombined into new combinations. These combinations can again be taken apart, and the mineral we thought destroyed can soon be restored to its original perfection.

The main characteristic of minerals that concerns us here is the indifference their components show toward the form of their combination, that is, their coordination or subordination. There are, by nature, stronger or weaker bonds between these components, and when they evidence themselves, they resemble attractions between human beings. This is why chemists speak of elective affinities, even though the forces that move mineral components [or humans] one way or another and create mineral structures are often purely external in origin, which by no means implies that we deny them the delicate portion of nature’s vital inspiration that is their due.

How different even imperfect organic beings are! They convert part of the nourishment they absorb—eliminating what they do not need—into distinct organs. What they do absorb they turn into something unique and exquisite by joining most intimately one element with another and so forming differentiated parts in whose forms multifarious life is manifested. And if these forms are destroyed, they cannot be reconstructed from what remains.

If we compare these imperfect organic beings with higher ones, we find that the former, even though they make use of elemental influences with a certain degree of force and individuality, cannot bring the resulting organic parts to the same level of specialization and permanence as the higher animal forms can. We know, for example, that plans—and we will not descend any lower on the scale of organic life—developing as they do in a certain sequence, represent one and the same basic organ in highly different shapes.

Detailed insight into the law governing this metamorphosis will surely advance the science of botany, not only in its descriptive tasks but also in its efforts to understand the inner nature of plants.”

Here, in first section, we see, in excellent form, Goethe discussing "human chemical bonding" in the context of the affinity forces, which he correctly says are "external in origin", that create or dissolve such combinations. In this last section, Goethe touches on the life from non-life issue, where he says "we will not descend any lower on the scale of organic life", and foreshadows the laws of evolution (or "law governing this metamorphosis"), as introduced by Charles Darwin in 1859.

Students
A noted student of Eigen’s is Polish physicist Michal Kurzynski, author of the 2006 book The Thermodynamic Machinery of Life. [3]

Other
In 1967, Eigen, along with Ronald Norrish and George Porter, was awarded the Nobel Prize in chemistry for studies of extremely fast chemical reactions induced in response to very short pulses of energy.

References
1. (a) Eigen, Manfred (1971). “Self-organization of Matter and the Evolution of Biological Macromolecules” ("Molekulare Selbstorganisation und Evolution"), Naturwissenschaften, 58(10):465-523.
(b) Brooks, Daniel R. and Wilson, E.O. (1988). Evolution as Entropy: Toward a Unified theory of Biology (pg. 76). University of Chicago Press.
2. (a) Goethe, Johann. (1796). “On the Laws of Organization as Such, to the Extent That We Can Observe Them in the Structure of Types”, Lectures on Comparative Anatomy and Zoology.
(b) Eigen, Manfred, and Winkler, Ruthild. (1981). Laws of the Game: How the Principles of Nature Govern Chance (pg. 74-77). Princeton University Press.
3. Kurzynski, Michal. (2006). The Thermodynamic Machinery of Life. Springer.
4. (a) Eigen, Manfred. (1971). “Self-organization of Matter and the Evolution of Biological Macromolecules”, Die Naturwissenschaften, 58(10):465-523, Oct.
(b) Schoffeniels, Ernest. (1973). Anti-Chance: a Reply to Monod’s Chance and Necessity (L’Anti-Hasard) (Amz) (translator: B.L. Reid) (pgs. 98-99). Pergamon, 1976.
(c) Quasispecies model – Wikipedia.

Further reading
● Dyson, Freeman. (1999). Origins of Life (§:Eigen and Orgel, pgs. 11-) (pdf). Cambridge.

External links
Manfred Eigen – Wikipedia.
Manfred Eigen (videos) – WebOfStories.com.

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